I AM A LOOKING TO GO

What’s causing this patient’s spontaneous laughter?

Figure 1 Quiz of the Week A 45-year-old female presents with painful lesions on her lower limbs and ears. She is a smoker, and has a history of recreational drug use. Purpuric, necrotic lesions are noted on both lower extremities, in addition to tender purpura on both ears. A biopsy is performed which demonstrates leukocytoclastic…

Macroglossia and edema—what do you suspect

Figure 1 Quiz of the Week A 65-year-old male presents to his family physician with complaints of increasing fatigue, dyspnea on exertion, and unintentional weight loss within the last six months. On examination, he is noted to have macroglossia and peripheral edema. Crackles are audible bilaterally on chest auscultation. Image credit: @nikhilchadha.   Answer: Bone marrow…